GPT-4o excels at multimodal tasks with native audio support and lower latency, while Claude 3.7 Sonnet offers superior reasoning with its extended thinking mode and a 200K context window. Both support vision, but Claude tends to produce more nuanced, carefully structured responses for complex analytical tasks.

GPT-4o is OpenAI's flagship multimodal model — it's faster and cheaper than GPT-4 Turbo, handles text, audio, and images natively, and has 128K context. Claude 3.7 Sonnet from Anthropic adds an extended thinking mode for step-by-step reasoning, a larger 200K context window, and tends to be more careful with complex instructions.